Questões para Concursos

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Text I Correspondence Human genome editing: potential seeds of conflict Recently, The Lancet published an important declaration regarding the necessity of regulating and legislating for human genome editing. We agree with their opinions that the human genome editing technology and resulting research can have both positive and negative effects on human society. The use of genome editing for research and commercial purposes has sparked debates in both biological and political realms. However, most of them have mainly focused on the effects of human genome editing on the patients themselves, and little attention has been paid to their offspring. Several films, such as Gattaca and Gundam SEED, have addressed the conflicts that arise from human genome editing. Such conflicts not only exist within the generation who have experienced editing but are also transmitted to their offspring. For example, in these films, the offspring of people without genome editing felt a sense of unfairness regarding the inferiority of their physical (or other non-edited domains) status, whereas the offspring of people with genome editing grew up in a biased, discriminated against, and ostracized environment. They could have lived in peace with a strong and well regulated government; however, when the tenuous grip of government weakens, jealousy and resentment can lead to ruins. Although these scenes still exist in films, they might become increasingly plausible in decades to come. Using the concept of preparedness, access, countermeasures, tools, and trust, we should prepare legitimate human genome editing, establish access to deal with imminent or potential discrimination, develop countermeasures and tools for prevention and resolution of conflict, and entrust future generations with the responsibility to use them wisely. Bing-Yan Zeng, Ping-Tao Tseng, *Chih-Sung Liang Adapted from: www.thelancet.com, vol. 401, June 24, 2023 at https://www.thelancet.com/action/showPdf?pii=S0140-6736%2823%2901084-X

Read the

Text I and answer the question that follow it.

Text I Correspondence Human genome editing: potential seeds of conflict Recently, The Lancet published an important declaration regarding the necessity of regulating and legislating for human genome editing. We agree with their opinions that the human genome editing technology and resulting research can have both positive and negative effects on human society. The use of genome editing for research and commercial purposes has sparked debates in both biological and political realms. However, most of them have mainly focused on the effects of human genome editing on the patients themselves, and little attention has been paid to their offspring. Several films, such as Gattaca and Gundam SEED, have addressed the conflicts that arise from human genome editing. Such conflicts not only exist within the generation who have experienced editing but are also transmitted to their offspring. For example, in these films, the offspring of people without genome editing felt a sense of unfairness regarding the inferiority of their physical (or other non-edited domains) status, whereas the offspring of people with genome editing grew up in a biased, discriminated against, and ostracized environment. They could have lived in peace with a strong and well regulated government; however, when the tenuous grip of government weakens, jealousy and resentment can lead to ruins. Although these scenes still exist in films, they might become increasingly plausible in decades to come. Using the concept of preparedness, access, countermeasures, tools, and trust, we should prepare legitimate human genome editing, establish access to deal with imminent or potential discrimination, develop countermeasures and tools for prevention and resolution of conflict, and entrust future generations with the responsibility to use them wisely. Bing-Yan Zeng, Ping-Tao Tseng, *Chih-Sung Liang Adapted from: www.thelancet.com, vol. 401, June 24, 2023 at https://www.thelancet.com/action/showPdf?pii=S0140-6736%2823%2901084-X

Read the Text II and answer the question that follow it. Text II Global plastic treaty should address chemicals In March, the global community agreed to establish a legally binding treaty to end plastic pollution. To deliver on this goal, the treaty needs to cover all issues of plastics chemicals as an inseparable part of the problem. Plastics are complex materials consisting of chemical mixtures, including polymers, additives, residual monomers and processing aids, and non-intentionally added substances. Such mixtures release across the plastics life cycle, from feedstock extraction, production, and use, to reuse, recycling, and disposal; they also recombine along complex, unplanned pathways. As a result, humans and environments are ubiquitously exposed to plastics chemicals, often with serious consequences. Out of more than 10,000 known plastics chemicals, at least 2,400 are classified as toxic, such as many phthalates and brominated flame retardants. Documented health effects span generations and include premature births, low birth weight, obesity, diabetes, cardiovascular disease, endometriosis, infertility, and cancers. In the United States alone, associated costs of endocrine-disrupting chemicals amount to USD$300 billion/year. The total burden on community, ecosystem health, and biodiversity is far greater. Even with material recycling, plastics chemicals ultimately proliferate in the ecosystem, whether as emissions or by entering new products, exposing waste-laborers, consumers, and frontline communities to new chemical cocktails. An effective, fair, and safe circular economy can only be achieved by phasing out toxic chemicals from plastic production. As negotiations for a global treaty begin, plastics chemicals need to be front and center. However, preparatory meeting documents focus on downstream plastic waste and work from a narrow definition of chemicals as hazardous additives. To enable the treaty to fully address plastics’ ecological, health, and environmental justice problems, it is essential to redefine plastics as complex chemical mixtures and to integrate chemical issues across the life cycle within the scope and core obligations of the legal instrument. Adapted from: https://www.science.org/doi/10.1126/science.adf5410.

Read the Text II and answer the question that follow it. Text II Global plastic treaty should address chemicals In March, the global community agreed to establish a legally binding treaty to end plastic pollution. To deliver on this goal, the treaty needs to cover all issues of plastics chemicals as an inseparable part of the problem. Plastics are complex materials consisting of chemical mixtures, including polymers, additives, residual monomers and processing aids, and non-intentionally added substances. Such mixtures release across the plastics life cycle, from feedstock extraction, production, and use, to reuse, recycling, and disposal; they also recombine along complex, unplanned pathways. As a result, humans and environments are ubiquitously exposed to plastics chemicals, often with serious consequences. Out of more than 10,000 known plastics chemicals, at least 2,400 are classified as toxic, such as many phthalates and brominated flame retardants. Documented health effects span generations and include premature births, low birth weight, obesity, diabetes, cardiovascular disease, endometriosis, infertility, and cancers. In the United States alone, associated costs of endocrine-disrupting chemicals amount to USD$300 billion/year. The total burden on community, ecosystem health, and biodiversity is far greater. Even with material recycling, plastics chemicals ultimately proliferate in the ecosystem, whether as emissions or by entering new products, exposing waste-laborers, consumers, and frontline communities to new chemical cocktails. An effective, fair, and safe circular economy can only be achieved by phasing out toxic chemicals from plastic production. As negotiations for a global treaty begin, plastics chemicals need to be front and center. However, preparatory meeting documents focus on downstream plastic waste and work from a narrow definition of chemicals as hazardous additives. To enable the treaty to fully address plastics’ ecological, health, and environmental justice problems, it is essential to redefine plastics as complex chemical mixtures and to integrate chemical issues across the life cycle within the scope and core obligations of the legal instrument. Adapted from: https://www.science.org/doi/10.1126/science.adf5410.

Read the Text II and answer the question that follow it. Text II Global plastic treaty should address chemicals In March, the global community agreed to establish a legally binding treaty to end plastic pollution. To deliver on this goal, the treaty needs to cover all issues of plastics chemicals as an inseparable part of the problem. Plastics are complex materials consisting of chemical mixtures, including polymers, additives, residual monomers and processing aids, and non-intentionally added substances. Such mixtures release across the plastics life cycle, from feedstock extraction, production, and use, to reuse, recycling, and disposal; they also recombine along complex, unplanned pathways. As a result, humans and environments are ubiquitously exposed to plastics chemicals, often with serious consequences. Out of more than 10,000 known plastics chemicals, at least 2,400 are classified as toxic, such as many phthalates and brominated flame retardants. Documented health effects span generations and include premature births, low birth weight, obesity, diabetes, cardiovascular disease, endometriosis, infertility, and cancers. In the United States alone, associated costs of endocrine-disrupting chemicals amount to USD$300 billion/year. The total burden on community, ecosystem health, and biodiversity is far greater. Even with material recycling, plastics chemicals ultimately proliferate in the ecosystem, whether as emissions or by entering new products, exposing waste-laborers, consumers, and frontline communities to new chemical cocktails. An effective, fair, and safe circular economy can only be achieved by phasing out toxic chemicals from plastic production. As negotiations for a global treaty begin, plastics chemicals need to be front and center. However, preparatory meeting documents focus on downstream plastic waste and work from a narrow definition of chemicals as hazardous additives. To enable the treaty to fully address plastics’ ecological, health, and environmental justice problems, it is essential to redefine plastics as complex chemical mixtures and to integrate chemical issues across the life cycle within the scope and core obligations of the legal instrument. Adapted from: https://www.science.org/doi/10.1126/science.adf5410.